Faculty Profile

Dr. Sabyasachi Senapati
Assistant Professor
Department of Human Genetics and Molecular Medicine
School of Health Sciences
Central University of Punjab
Bathinda- 151001
Email Id: sabyasachi1012@gmail.com; s.senapati@cup.edu.in 
Mobile:+91-9953643083

 
Education :
Degree
Name of the Institute Year
Ph.D

Department of Genetics, University of Delhi South Campus, New Delhi, India.

2008-2013
M.Phil

Department of Zoology, University of Delhi, Delhi, India.

2007-2008
M.Sc.

Department of Zoology, University of Delhi, Delhi, India.

2005-2007
B.Sc.

Serampore College, University of Calcutta, Kolkata, India.

2002-2005
Experience :
Name of the Institute Position Period
Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, India
Nature of Work: Teaching & mentoring M.Sc and Ph.D students and Research; social and administrative
responsibilities
Assistant Professor Aug 2015 – till date
Department of Zoology, Ramjas College, University of Delhi, Delhi, India
Nature of Work: Teaching Under-graduate students
Assistant Professor Feb 2014 – Aug 2015
Department of Human Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
Nature of Work: Worked with Prof.Cisca Wijmenga’s research group as a visiting PhD fellow. Participated in
International consortium for Celiac disease as a team member from Prof. Thelma B.K’s Group at University of Delhi
South Campus, New Delhi, India
Visiting PhD Fellow Mar 2011 – Sept 2011
Teaching Assignments :

Presently teaching:
M.Sc Human Genetics; and M.Sc Life Sciences, PhD Human Genetics, and Molecular Medicine.

Master of Science:
Semester-I: Biostatistics & Research Methodology (LHG.506), Concepts of Genetics (LHG.512).
Semester-II: Human Embryology & Developmental Genetics (LHG.525), Population Genetics & Genetic Epidemiology
(LHG.526).
Semester-III: Bioinformatics and Computational Biology (LHG.550), Pharmacogenomics & Nutrigenomics (LHG.553).
Semester-IV: Recombinant DNA technology and Therapeutics (LHG.571).
Ph.D Coursework: Research methodology and Biostatistics (LHG.701).

Supervised as Mentor

M.Sc. = 23
PhD: 02 (ongoing)
Project JRF: 01
UGC JRF: 01
DST Women Scientist (WOS-A) Fellow: 01

Professional Recognition /Awards/Scholarship :
  1. Young Scientist Travel Award, International Congress of Human Genetics, April. 2016, Kyoto, Japan.
  2. Young Scientist Award, Association of Biotechnology & Pharmacy, Oct. 2013, New Delhi, India.
  3. Visiting graduate student fellowship (Mar2011– Sept 2011) by University Medical Centre Groningen, Groningen, The
    Netherlands.
  4. CSIR Junior research fellowship (2007, 2008)
  5. Qualified for prestigious Dr. Shyama Prasad Mukherjee (SPM) Fellowship - CSIR, Dec. 2007 and June 2008
Area specializations/Research Interest :

Specific areas of interest are:

  • Complex disease genetics (Celiac disease, COPD, Granulomatosis with polyangiitis)
  • Systems biology
  • Population genomics

Our research group aiming to contribute for improving public health globally. Currently we are interested in working with high-throughput “Omics” data to investigate the cause for onset of immune mediated diseases, their early prediction and identify probable drug targets for their treatment. We are utilizing several biostatistical, bioinformatics and computational tools to solve the puzzle of immune related diseases. Another part of our research is focused on trans-ethnic comparison of genome-wide data to understand evolutionary aspect of human diseases. Laboratory is presently working on in silico analyses of clinical and epidemiological data, using bioinformatics and biostatistical tools to address major public health crisis, in vitro validation of identified disease associated genes.

Publications :

Reasearch Papers

  1. Sharma, N. Singh, K. Senapati, S. Celiac disease poses significant risk in developing neuropsychiatric diseases: A metaanalysis. Submitted.
  2. Bhagavatula, S. Banerjee, P. Sood, A. Midha, V. Thelma, BK. Senapati, S. Energy metabolism genes with synergistic
    functions identified in celiac disease. Submitted.
  3. Bhattacharya, N. Maurya, SK. Senapati, S. Bhattacharya, A. Drug repurposing: A strategy to treat human coronavirus
    disease (COVID-19). Submitted.
  4. Sharma, N. Bham, K. Senapati, S. Human Ankyrins and their contribution in disease biology: A Recent Update. Journal of
    Biosciences. 2020. (In Press). (IF:1.65)
  5. Senapati, S. Banerjee, P. Bhagavatula, S. Kushwaha, PP. Kumar, S. Contributions of human ACE2 and TMPRSS2 in
    determining host-pathogen interaction in COVID-19. Journal of Genetics. 2020. (In Press). (IF:0.99)
  6. Senapati, S. Kumar, S. Singh, AK. Banerjee, P. Bhagavatula, S. Assessment of risk conferred by coding and regulatory
    variants of TMPRSS2 and CD26 in susceptibility of SARS-CoV-2 infection in human. Journal of Genetics. 2020. 99(1):53.
    (IF:0.99)
  7. Gupta, S. Singh, AK. Kushwaha, PP. Prajapati, KS. Shuaib, M. Senapati, S. Kumar S. Identification of potential natural
    inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies. Journal of Biomolecular &
    Structural Dynamics. 2020. 11:1-12. (IF:3.31)
  8. Banerjee, P. Bhagavatula, S. Sood, A. Midha, V. Thelma, BK. Senapati, S. Association study identified biologically relevant receptor genes with synergistic functions in celiac disease. Scientific Reports. 2019. 9(1):13811. doi:10.1038/s41598-019- 50120-4. (IF:4.53)
  9. Khanna, R. Nandy, D. Senapati, S. Sysematic review and meta-analysis to establish the association of common genetic
    variations in vitamin D binding protein with chronic obstructive pulmonary disease. Frontiers in Genetics. 2019. 10:413.
    doi: 10.3389/fgene.2019.00413. (IF: 4.15)
  10. Nandy, D. Sharma, N. Senapati, S. Systematic review and meta-analysis confirms significant contribution of surfactant
    protein D in chronic obstructive pulmonary disease. Frontiers in Genetics. 2019. 10:339. doi: 10.3389/fgene.2019.00339.
    (IF: 4.15)
  11. Chaudhary, D. Sharma, N. Senapati, S. Serum homocysteine could be used as a predictive marker for chronic obstructive
    pulmonary disease: A Meta-analysis. Frontiers in Public Health. 2019. 7:69. doi:10.3389/fpubh.2019.0069. (IF: 2.03 )
    3
  12. Marquez, A. Kerick, M. Coeliac Disease Immunochip Consortium. et al. Meta-analysis of Immunochip data of four
    autoimmune diseases releals novel single-disease and cross-phenotype associations. Genome Med. 2018.20;10(1):97.
    doi: 10:1186/s13073-018-0604-8. (IF:8.90)
  13. Senapati, S. Sood, A. Midha, V. Sood N. Sharma, S. Kumar, L. Thelma B.K. Shared and unique genetic determinants
    between pediatric and adult celiac disease. BMC Medical Genomics, 2016, 9(1):44. (IF: 3.32)
  14. Senapati, S. Bharti, N. Bhattacharya, A. Modern lifestyle diseases: chronic diseases, awareness and prevention. Int J Curr
    Res Acad Rev. 2015;3(3),215-3. (IF:--)
  15. Senapati, S. Gutierrez-Achury, J. Sood, A. Midha, V. Szperl, A. Romanos, J. Zhernakova, A. Franke, L. Thelma, B.K.
    Wijmenga, C. Trynka, G. Evaluation of European coeliac disease risk variants in a North Indian population. European
    Journal of Human Genetics, 2015;23(4):530-5. (IF: 4.35)
  16. Juyal, G. Negi, S. Sood, A. Senapati, S. Gupta, A. Prasad, P. Singh, S. Zaneveld, J. Midha, V. van Sommeren, S. Weersma, R.K. Ott, J. Jain, S. Juyal, R.C. Thelma, B.K. Genome-wide association scan in a north Indian cohort identifies three novel HLA independent susceptibility loci in ulcerative colitis. Gut, 2015;64(4):571-9. (IF: 17.02)
  17. Senapati, S. Singh, S. Das, M. Kumar, A. Gupta, R. Kumar, U. Jain, S. Juyal, R.C. Thelma, B.K. Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis reveals novel risk variants and leads for TYMS regulation.
    Pharmacogenetics and Genomics, 2014:24(4):211-9. (IF: 2.25)
  18. Negi, S. Juyal, G. Senapati, S. Prasad, P. Gupta, A. Singh, S. Kashyap, S. Kumar, A. Kumar, U. Gupta, R. Kaur, S. Agrawal, S. Aggrawal, A. Ott, J. Jain, S. Juyal, R.C. Thelma, B.K. A genome-wide association study reveals ARL15, a novel non-HLA susceptibility gene for Rheumatoid arthritis in north Indians. Arthritis & Rheumatology, 2013;65(12):3026-35. (IF: 6.92)
  19. Trynka, G. Hunt, K.A. Bockett, N.A. Romanos, J. Mistry, V. Szperl, A. Bakker, S.F. Bardella, M.T. Bhaw-Rosun, L. Castillejo, G. de la Concha, E.G. de Almeida, R.C. Dias, K.R. van Diemen, C.C. Dubois, P.C. Duerr, R.H. Edkins, S. Franke, L. Fransen, K. Gutierrez, J. Heap, G.A. Hardlickova, B. Hunt, S. Plaza Izurieta, L. Izzo, V. Joosten, L.A. Langford, C. Mazzilli, M.C. Mein, C.A. Midha, V. Mitrovic, M. Mora, B. Morelli, M. Nutland, S. Nunez, C. Onengut-Gumuscu, S. Pearce, K. Platteel, M. Polanco, I. Potter, S. Ribes-Koninckx, C. Ricano-Ponce, I. Rich, S.S. Rybak, A. Santiago, J.L. Senapati, S. Sood, A. Szajewska, H. Troncone, R. Varadé, J. Wallace, C. Wolters, V.M. Zhernakova, A. Spanish Consortium on the Genetics of Coeliac Disease (CEGEC). PreventCD Study Group. Wellcome Trust Case Control Consortium (WTCCC). Thelma, B.K. Cukrowska, B. Urcelay, E. Bilbao, J.R. Mearin, M.L. Barisani, D. Barrett, J.C. Plagnol, V. Deloukas, P. Wijmenga, C. van Heel, D.A. Dense genotyping identifies and localizes multiple common and rare variant association signal in celiac diseases. Nature Genetics, 2011; 6;43(12):1193-201. (IF: 27.13)
  20. Garima, J. Prasad, P. Senapati, S. Midha, V. Sood, A. Amre, D. Juyal, R.C. Thelma, B.K. An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians. PLoS ONE, 2011; 6(1): e16565. (IF: 2.77)


View my publications at:
Google Scholar Citation: https://scholar.google.co.in/citations?hl=en&user=_QX2EpsAAAAJ
Research Gate: https://www.researchgate.net/profile/Sabyasachi_Senapati
Linkedin: https://www.linkedin.com/in/sabyasachi-senapati-18a89a39/

Popular Articles

  1. Personalized medicine: A hope for better public health. October. 2015. NE Scholar Magazine
  2. Vaccine Development: Trials, Approval Process and Ethical Issues. 2020, October. Dream 2047. Vigyan Prasar.

Books/Book Chapter

  1. Bhattacharya, A. Sharma, N. Bhattacharya, N. Senapati, S. In silico targets in immune response. Springer, Singapore. 2019. pp 393-402. doi: 10.1007/978-981-13-6920-9_21. eISBN: 978-981-13-6920-9.
  2. Sharma, N. Dhekne, HS. Senapati, S. Immunomodulatory potential of phytochemicals: Recent updates. Springer,
    Singapore. 2019. pp 133-10. doi: 10.1007/978-981-13-6920-9_8. eISBN: 978-981-13-6920-9.
  3. Senapati, S. Alternative Pathways for Glucose Metabolism. Nova Science Publishers. USA. 2017. ISBN.978-1-53612-
    907-6.
Workshop/Conferences :

Attended/Presented

Orientation and Refresher Courses

  1. Two Week Online Faculty Development Programme on “Managing Online Classes and Co-Creating MOOCS 3.0”. July
    25 – August 10, 2020. PMMMNMTT Teachin Learning Centre, Ramanujan College, University of Delhi, New Delhi, India.
  2. Science Academies’ Refresher Course on “Plant Taxonomy, Phytogeography and Ecology”. March 05 – March 20, 2019.
    Central University of Punjab, Bathinda, Punjab, India.
  3. UGC-Sponsored “Orientation Programme”. November 13 – December 10, 2018. UGC-HRDC, Punjab University,
    Chandigarh, India.


Workshops/Trainings:

  1. Genetic Epidemiological Research and Data Analysis. May 23-27, 2011. By Graduate School for Drug Exploration.
    University Medical Center Groningen, The Netherlands.
  2. International course on Epidemiological Methods. Organized by International Epidemiological Association. April 5-7,
    2009. Jaipur, India.
  3. Genetic Epidemiological Methods for Dissection of Complex Human Traits. Organized by TCG-ISI Centre for population
    genetics, Kolkata and University of Pittsburgh, Pittsburgh, U.S.A. Feb. 23-28, 2009. Kolkata, India.

Conferences and Symposiums:

  1. International Webinar on “Prospects of Natural Products on Human Health in Current Scenario”. June 24, 2020. Department of Botany, Banaras Hindu University, Varanasi, India.
  2. “International COVID-19 Conference”. May 15, 2020. Stanford Center for Continuing Medical Education, Stanford, CA, USA.
  3. 44th Annual Conference of the Indian Society of Human Genetics on “Genomics for Health and Precision Medicine”. Jan. 30th-Feb. 1st 2019. NIBMG & University of Kalyani, West Bengal. India.
  4. 1st National Biomedical Research Competition. October 15. 2018. AIIMS, Rishikesh, India.
  5. Recent Advances in Mlecular Genetics With New Biomedical Insights. An Indi-Israel Meeting. February 12-13. 2018.
    Indian National Science Academy (INSA), New Delhi, India.
  6. 17th International Celiac Disease Symposium. Sept. 8-10. 2017. Le Meridean, New Delhi, India.
  7. 42nd Annual Meeting of the Indian Society of Human genetics & International Symposium on Trends in Human Genetic
    Research & Management. March 2-4. 2017. Indian Institute of Science, Bengaluru, India.
  8. The 13th International Congress of Human Genetics. April 3-7, 2016. Kyoto International Conference Center, Kyoto, Japan.
  9. 7th Annual Convention of Association of Biotechnology and Pharmacy&International Conference on Plant Biotechnology, Molecular Medicine & Human Health. October 18-20, 2013. University of Delhi South Campus. New Delhi. India
  10. National Science Day Symposium-2013. February 27-28, 2013. University of Delhi South Campus, New Delhi.
  11. International conference on Genes, Genetics and Genomics: Today and Tomorrow-Human concerns and XXXVII annual conference of The Indian Society of Human Genetics. March 3-5, 2012. Panjab University, Chandigarh, India.
  12. National Science Day Symposium-2012. February 27-28, 2012. University of Delhi South Campus, New Delhi.
  13. 12th International Congress of Human Genetics & 61st American Society of Human Genetics. October 11-15, 2011. Montreal, Canada.
  14. InternationalNetworking Conference: From DNA to Phenotype. March 9 – 11, 2011. Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  15. International conference on Molecular and Clinical aspects of Gonadal and Non-gonadal actions of Gonadotropins. February 7-9, 2008. New Delhi. India. Organized by Department of Reproductive Biology, All Indian Institute of Medical Sciences, New Delhi, India
  16. 30th All Indian Cell Biology Conference & Symposium on Molecules to Compartments: Cross-Talk and Networks. February 2-4, 2007. New Delhi. India. Organized by Department of Zoology, University of Delhi and Indian Society of Cell Biology.

Meetings:

  1. 6th National IBD Meet on IBD. September 15-16, 2018. Convention Centre, Hotel Pullman, New Delhi. Organized by
    Colitis and Crohn’s Foundation (India).
  2. 3rd National IBD Meet on IBD in different ethnic groups: East vs. West? September 29-30, 2012. Gurgaon, Haryana,
    India. Organized by Colitis and Crohn’s Foundation (India).
  3. 2nd National IBD Meet on Understanding the enigma of IBD in India. May 23, 2010. New Delhi, India. Organized by
    Colitis and Crohn’s Foundation (India).
  4. Satellite meeting of HGM 2008 on Clinical Genomics. September25, 2008. New Delhi, India. Organizedby Indian Council
    for Medical research

Organized

Workshops/Trainings:

  1. Organizing Member. “Indian Traditional Medicine in Cancer Therapy and Prevention”. February 4th, 2020. Central University of Punjab, Bathinda.
  2. Organizing Member. “Expert Lectures on Cancer Prevention and Awareness”. February 3rd, 2020. Central University of Punjab, Bathinda.
  3. Organizing Secretary. Special lectures on “Genomic Medicine” & Workshop on “Molecular Modelling & Developmental Genetics”. March 24-25, 2017. Central University of Punjab, Bathinda, Punjab.
  4. Organizing Member. DBT-Sponsored Training Course in Medical Genetics and Bioinformatics. March 9-23, 2016. Central University of Punjab, Bathinda, India.
  5. Organizing Secretary. Workshop on Model Organisms in Molecular Genetic Research. March 21, 2016. Central University of Punjab, Bathinda, Punjab.
Invited Lectures and Talks
  1. Invited talk at National Symposium on “Recent Trends and Ethics in Biological Research” March 7, 2020. Dyal Singh College, University of Delhi, New Delhi
  2. Invited talk at 2nd National Seminar on “Responsible Research and Innovations in Science & Technology” (RRIST-2020), February 29, 2020. Guru Nanak College, Punjabi University, Budhlada
  3. Talk on “Genome-wide association study identified several novel genes and BMP associated pathways with bone erosion in rheumatoid arthritis” at 44th Annuam Conference of Indian Society of Human Genetics. Jan 31st-1st feb, 2019. Kalyani University, West Bengal. India
  4. Lecture on “Strategies for Linkage and Association mapping”, at DBT-Sponsored Training Course in Medical Genetics and Bioinformatics. March 9-23, 2016. Central University of Punjab, Bathinda, India
  5. Lecture on “Introduction to Biostatistics”, at DBT-Sponsored Training Course in Medical Genetics and Bioinformatics.s March 9-23, 2016. Central University of Punjab, Bathinda, India
Laboratory Projects

Sr. No.

Ongoing Projects

Funded By & Duration

Tenure

1.

In silico evaluation of non-coding genome involved in Immune-mediated diseases
(PI)

Central University of Punjab
(Research Seed Money)

(2016-18)

2.

Identification of non-coding RNA in celiac disease
(PI)

University Grant Commission (BRS)

(2017-19)

3. Investigation of non-coding genome mediated gene
expression regulation in celiac disease
(PI)
Science & Engineering Research Board (DST)
(Early Career Research Grant)
(2017-20)
4. Functional genomics of ANK3 implicated in celiac disease (Mentor) DST Women Scientist-A research grant (to Ms. Nidhi Sharma) (2019-21)
5. Clinical and Molecular Characterization of Primordial Dwarfism (Pd) in Indian Patients
(Co-PI)
ICMR (Task Force for Rare Disorders) (2019-2022)
6. An Indian Initiative To Study Granulomatosis With
Polyangiitis Through Clinical And Genomics Approach
(PI)
ICMR (Task Force for Rare Disorders) (2019-2022)
Academic and Administrative Assignments
  1. Member, Academic and Administrative Committee (AAC), Department of Human Genetics & Molecular Medicine, Central University of Punjab .
  2. Member, Curriculum Development Committee (CDC), Department of Human Genetics & Molecular Medicine, Central University of Punjab.
  3. Member, Board of Studies (BOS), Department of Human Genetics & Molecular Medicine, Central University of Punjab.
  4. Member, School Board, School of Health Sciences, Central University of Punjab.
  5. Member, Institutional Ethics Committee (IEC), Central University of Punjab.
  6. Program Officer, NSS, Central University of Punjab.
Professional Membership
  1. Life Member of Indian Society of Human Genetics (ISHG), Hyderabad, India.
  2. Life Member of Indian Society of Cell Biology (ISCB), Varanasi, India.
  3. Life Member of International Society for Study of Celiac Disease (ISSCD), Hague, Netherlands.
Collaboration
  1. Professor. Thelma B.K, Department of Genetics, University of Delhi South Campus, New Delhi, India
  2. Professor. Uma Kumar, Head, Department of Rheumatology, AIIMS, New Delhi, India
  3. Professor. Ajit Sood and Dr. Vandana Midha, Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
  4. Dr. Vitull K. Gupta, Department of Medicine. Adesh Institute of Medical Sciences and Research, Bathinda, Punjab. India.
  5. Dr. Chetana Sachidanandan. CSIR-Institute of Genomics and Integrative Biology. New Delhi, India.
  6. Member of Coeliac Disease Immunochip Consortium, The Netherlands.